A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex. A local Wnt-3a signal is required for development of the mammalian hippocampus. Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1. The germinal matrices in the developing dentate gyrus are composed of neuronal progenitors at distinct differentiation stages. Prox1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesis. Cues, context, and long-term memory: the role of the retrosplenial cortex in spatial cognition. The hippocampus and memory: insights from spatial processing. These data provides a blueprint for understanding human hippocampal development and a tool for investigating related diseases.īird, C. Transient expression of the primate-specific gene NBPF1 leads to a marked increase in PROX1 + cells in the mouse hippocampus. The molecular features of the human hippocampus at gestational weeks 16–20 are similar to those of the mouse at postnatal days 0–5 and reveal gene expression differences between the two species. We also illustrate spatially specific gene expression in the developing human prefrontal cortex and hippocampus. Multiomic data have uncovered transcriptional regulatory networks of the dentate gyrus marker PROX1. We also identify the migrating paths and cell lineages of PAX6 + and HOPX + hippocampal progenitors, and regional markers of CA1, CA3 and dentate gyrus neurons. Using the transcriptomes of 30,416 cells from the human hippocampus at gestational weeks 16–27, we identify 47 cell subtypes and their developmental trajectories. Here we use single-cell RNA sequencing and assay for transposase-accessible chromatin using sequencing (ATAC–seq) analysis to illustrate the cell types, cell linage, molecular features and transcriptional regulation of the developing human hippocampus.

The hippocampus is an important part of the limbic system in the human brain that has essential roles in spatial navigation and the consolidation of information from short-term memory to long-term memory 1, 2.

Hippocampus band management